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Omics! Omics! Omics! Omics! A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery Tuesday, July 31, 2018 Two Museums Guaranteed to Fluor You I've been horribly neglecting this space for an extended period. Contributors to that include a TNG eclosing from upper school, ferrying grandparents, a milestone (or is it millstone?) birthday and a 10 day vacation with poor Internet service. Oh yeah, flipside one of those starts Thursday. Then there's keeping the genome factory going -- at times I finger like a worker in Fritz Lang's Metropolis. But someone plane noticed and emailed me today whether this hiatus would end, which is vastitude reason unbearable to get going. But tonight's entry has nothing really to do with biology or genomics, but rather hearkens when to the first science I fell for. Read increasingly » Posted by Keith Robison at 11:45 PM No comments: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Monday, June 18, 2018 LC2018: VolTRAX In my preview superiority of London Calling, I suggested that VolTRAX is a device that still hasn't found its raison d'etre. With the meeting, the device officially pre-launched and the visitor is now taking pre-orders for wordage in the Fall. And it still feels like a device which hasn't yet found its purpose, though Clive Brown presented a dazzling (if perhaps distant) vision of where VolTRAX might go. Read increasingly » Posted by Keith Robison at 11:18 PM No comments: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Wednesday, June 13, 2018 LC2018: Flongle, Ubik-a-something and Metricoin London Calling has been over for nearly three weeks. I originally wanted to write up at least something without the first night, but fatigue overcame me and I didn't get anything useful put together. And then travel and increasingly fatigue set in. But vastitude that and the usual temptation to procrastinate, there is the rencontre of forming a coherent narrative from all the variegated threads at the meeting. There's all the Oxford Nanopore official announcements and then various user presentation tidbits. Withoutseveral failed mental attempts to etch a big picture take on everything, I've decided to try to write a series (number yet indeterminate) of posts that will focus of various axes of the meeting. Hopefully they won't be to redundant -- or self-contradictory -- and that by pursuit one particular thread I can unquestionably condense some coherent thoughts. This first such thread starts with Flongle. Read increasingly » Posted by Keith Robison at 11:20 PM No comments: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Wednesday, May 23, 2018 Miscellaneous & Disorderly Thoughts on the Eve of London Calling It's the night surpassing London Calling. I hope to post Thursday, but an after-meeting report won’t be until nest week - I must soupcon on Friday fir a slightly insane/exhilarating routing to meet my family in Florida for the holiday weekend. Exhilarating as I will have a tarriance in one of the warmed-over capitals of Europe, Lisbon, which I’ve never visited. Insane, considering it’s a 12 hour overnight layover. Anyway, between the rencontre of tent Oxford Nanopore's expanding reach of products and applications and stuff sleep-addled from taking the redeye flight I'm going to throw out a tuft of thoughts without really trying to fuse them into a coherent narrative. Read increasingly » Posted by Keith Robison at 5:11 PM 1 comment: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Tuesday, May 22, 2018 Should PentaSaturn Buy An iSeq: A Hypothetical Scenario Illustrating Platform Picking Editorial note: I wrote this in early January, then planned to slot it in without some other items. Then life knocked me upside the head, then AGBT came withal and then it was forgotten. Once I remember it, I fretted it had gone stale. But I had put a lot of effort into it and really nothing has reverted with regard to iSeq, other than it should be shipping now. Besides, this week is London Calling and so having an Illumina-centric piece could be a bit of useful balance. So, for your consideration: Some of the online discussion virtually this January's iSeq announcement, springing from my piece or elsewhere, explores how the iSeq fits into the sequencing landscape. In particular, how does it fit in with Illumina's existing MiniSeq and MiSeq and how does it go versus Oxford Nanopore's MinION. For example, in Matthew Herper's Forbes piece, genomics maven Elaine Mardis compares iSeq unfavorably to MiSeq in terms of cost-per-basepair. I'm a huge parishioner in fitting sequencing to ones scientific and practical realities and not the other way 'round: no one platform quite fits all situations nor do plane the same metrics fit all situations. So in this piece, I'm going to illustrate what I believe is a plausible scenario in which iSeq would make sense. Now, I have designed this to play to iSeq's characteristics and very realistically have many dials which I could turn to go in flipside direction. Which I will try to note as I go along. Read increasingly » Posted by Keith Robison at 6:23 PM 1 comment: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Thursday, May 03, 2018 PromethION Racing: A Call To The Post I was at a get-together yesterday for bioinformatics folks associated with Third Rock Ventures companies at a local pub. The organizer, who I've known for a number of years, was introducing me with the pleasant "Keith writes a nice blog" -- but then the whisker "but he hasn't posted in a while". Ouch! But it hurts considering it's true; too many excuses to not write and far too many half-baked ideas and interviews that should be out (or worse, a nearly well-constructed post). Since it is May, which in the U.S. is bookended by iconic racing events, I'd like to trot out an idea that has been idling for a while: PromethION Racing. Read increasingly » Posted by Keith Robison at 11:18 PM 1 comment: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Monday, April 16, 2018 Mission Bio Launches Custom PanelsWhenin October I covered the launch of Mission Bio's single lamina platform, Tapestri. Tapestri is a microfluidic platform which encapsulates cells and sets of barcoded primers into droplets, lyses the cells within the droplets and executes PCR on the released DNA. Mission initially targeted hematologic cells, since they do not require disaggregation, and offered a standard panel of primes. Virtuallythe time of AGBT, Mission launched a custom panel option and took the time to sit lanugo with me. Now with AACR, Mission has spoken placing Tapestri at multiple major cancer centers: the NCI, Mt. Sinai, MD Anderson, Memorial Sloan Kettering, St. Jude's, UCSF, U Penn and Washington University. Read increasingly » Posted by Keith Robison at 8:14 AM No comments: Links to this post Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest Older Posts Home Subscribe to: Posts (Atom) About Me Keith Robison Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to wield these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility.Withouta unenduring bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. Other recurring notation in this blog are his loyal Shih Tzu Amanda and his teenaged son plume TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can moreover follow him on Twitter as @OmicsOmicsBlog. 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SEQanswers Pathogens: Genes and Genomics NGS Leaders Digithead's Lab Notebook Next Gen Sequencing Blog Daily Scala Gene Genie Eye on DNA GenomeWeb Discovering Biology in a Digital World Public Ramblings (bioinformatics) Dr. Robison's LinkedIn Profile Research Blogging Icons SiteMeter for Omics! Omics! Omics! Omics! Feedburner Feed Evolgen Genetics & Health Panda's Thumb Post-genome Drug Discovery Links Molecular Future In The Pipeline Drug Truths Popular Posts London Calling: Notes on Brownian Commotion I'm overdue on writing up London Calling. I can partly vituperation a lightweight computer -- though rebooting it seems to have righted it for the ... Oxford Nanopore Doesn't Disappoint Oxford Nanopore's AGBT presentation should have just finished up, so the embargo is off. Oxford was kind unbearable to yack with me last ni... Illumina Unveils HiSeq Successor NovaSeq At today's J.P. Morgan Healthcare Conference Illumina made a number of small announcements -- some new partnerships, Firefly on track fo... Has Ion Torrent Taken A 318-Sized Lead over MiSeq? About a week ago, Ion Torrent's President Greg Fergus andThroneof Marketing Manesh Jain were kind unbearable to engage me in a nearly an hou... 10X Reveals Its Facets Perhaps the heavily predictable launch at AGBT this year is the library prep instrument for 10X Genomics. This Bay Area startup made a hug... Oxford's "No thanks, I've once got one" Oxford Nanopore today hosted a Google hangout titled " No thanks, I've once got one ". Only this morning did it occur to... Ion's S5 The Ion Torrent team rolled out a new sequencer line this morning, the S5. The S5, whose impending release had been tipped on the internet ... What Might Knock Illumina Off Its Perch? The big sequencing platform news this week is Roche's utterance that they are ending their collaborations aimed at developing new seq... iSeq! Illumina CEO Francis deSouza's J.P. Morgan Presentation did not disappoint. While humdrum financials and touting market dominance and a... The Road to Hell is Paved with Bioinformatics Formats If you really want to raise a bioinformaticist's thoroughbred pressure, loudly declare your new tool generates output in trademark new data formats... Google meta tag Other Blogs Panharmonicon Junk Charts Random Intel Software Blog Comments are moderated to alimony out spam! So you won't see your scuttlebutt right yonder -- but please trust that I will okay it ASAP if it is on-topic Simple theme. Powered by Blogger.
